黄建耿，博士，华中科技大学教授，硕士、博士研究生导师；河南中医药大学兼职硕士研究生导师

联系方式：jiangenghuang@hust.edu.cn

通讯地址：湖北省武汉市航空路13号药学院二号楼211室 邮编：430030

研究方向： 1）疾病（肝损伤、炎症、帕金森等）状态下药代动力学研究

2）新药研发非临床与临床药代动力学研究

教育背景

2003.09-2008.07 华中科技大学 博士学位

1999.09-2003.07 华中科技大学（原同济医科大学） 学士学位

工作经历

2024.05-至今 河南中医药大学 兼职硕士研究生导师

2012.04-至今 华中科技大学 副教授、教授

2008.10-2012.03 美国University of Nebraska Medical Center、University of Iowa 博士后

代表性课题

1. 企业委托项目：中国劲酒免疫调节等效成分群代谢途径及其免疫调控机制研究 2024.05-2025.04 课题编号：20241517

2. 企业委托项目：Y 型 PEG 化重组人生长激素注射液在老年人群中群体药代动力学研究 2024.03-2024.06 课题编号：20241108

3. 湖北省中医药管理局重点项目：抗 NASH 中药一类新药金线莲苷及其片剂非临床药代动力学研究 2023.05-2024.12 课题编号：ZY2023Z019

4. 企业委托项目：美洲大蠊抗人乳头瘤病毒作用成药性评价 2021.05-2023.12 课题编号：20211223

5. 湖北省重点研发计划项目：基于液质联用生物分析的化学创新药药代动力学关键技术研究 2020.09-2022.07 课题编号：2020BCB045

6. 国家自然科学基金项目：α-突触核蛋白调控uptake 2转运体：多巴胺受体激动剂抗帕金森降效机制研究2018.01-2021.12 课题编号：81773811

7. 国家自然科学基金项目：基于NTCP/Ntcp和BSEP/Bsep介导的胆汁酸转运受阻导致托伐普坦药物性肝损伤机理研究 2014.01-2016.12 课题编号：81302837

代表性论文

1. Yixin Hu^#, Jianyuan Wu^#, Bingyu Cheng, Rongli You, Xueyan Yin, Guiying Chen, Ling Yang, Yang Zhang, Luqin Si, Hongliang Jiang, Yongjun Zhang, Jianying Huang*, Jiangeng Huang*. Effect of food and polymorphisms in SLCO2B1, CYP3A4 and UGT1A4 on pharmacokinetics of abiraterone and its metabolites in Chinese volunteers. British Journal of Clinical Pharmacology. Jan 1 2024, 90(1):247-263 DOI:10.1111/bcp.15883.

2. Peng Cao^#, Jun Gan^#, Sanlan Wu^#, Yixin Hu, Bin Xia, Xiaoyue Li, Hongan Zeng, Bingyu Cheng, Huifan Yu, Fei Li, Luqin Si*, Jiangeng Huang*. Molecular mechanisms of hepatoprotective effect of tectorigenin against ANIT-induced cholestatic liver injury: Role of FXR and Nrf2 pathways. Food and Chemical Toxicology. Jun 20 2023, 178:113914. DOI: 10.1016/j.fct.2023.113914.

3. Liping Xiang^#, Jian Xu^#, Wanyu Liu^#, Yue Wu, Xin Jiang, Yixin Hu, Yao Zhang, Qiang Yang, Zhe Wang, Yuejun Yang, Sanlan Wu, Luqin Si, Jiangeng Huang*, Yongjun Zhang*. Metabolite profiling of Tartary buckwheat extracts in rats following co-administration of ethanol using UFLC - Q - Orbitrap high-resolution mass spectrometry. Separations, Dec 2 2022, 9(12), 407. DOI: 10.3390/separations9120407 (^#These authors contributed equally)

4. Peng Cao^#, Yue Wu^#, Yaping Li^#, Liping Xiang, Bingyu Cheng, Yixin Hu, Xin Jiang, Zhe Wang, Sanlan Wu, Luqin Si, Qiang Yang, Jian Xu*, Jiangeng Huang*. The important role of glycerophospholipid metabolism in the protective effects of polyphenols-enriched Tartary buckwheat extract against alcoholic liver disease. Food & Function, Sept 14 2022, 13(20): 10415-10425 DOI: 10.1039/D2FO01518H (^#These authors contributed equally)

5. Yixin Hu#, Jianyuan Wu#, Xin Jiang#, Guiying Chen, Yang Zhang, Luqin Si, Hongliang Jiang, Jiangeng Huang*, Jianying Huang*. Simultaneous determination of abiraterone and its five metabolites in human plasma by LC-MS/MS: Application to pharmacokinetic study in healthy Chinese subjects. J Pharm Biomed Anal. DOI: 10.1016/j.jpba.2022.114826 (#These authors contributed equally)

6. Sichan Li#, Sanlan Wu#, Weijing Gong, Peng Cao, Xin Chen, Wanyu Liu, Liping Xiang, Yang Wang*, Jiangeng Huang*. Application of population pharmacokinetic analysis to characterize CYP2C19 mediated metabolic mechanism of voriconazole and support dose optimization. Frontiers in Pharmacology Jan 3 2022;12:730826. DOI: 10.3389/fphar.2021.730826 (#These authors contributed equally)

7. Dan Wang, Minghui Sun, Ying Zhang, Zehong Chen, Shuya Zang, Genyun Li, Gao Li, Jiangeng Huang*, Luqin Si*. Enhanced therapeutic efficacy of a novel colon-specific nanosystem loading emodin on DSS-induced experimental colitis. Phytomedicine. Nov 1 2020, 78, 153293 DOI: 10.1016/j.phymed.2020.153293

8. Megesa Mafuru #, Sanlan Wu#, Sijie He, Xuan Lu, Jiangeng Huang*, Hongliang Jiang. The influence of proinflammatory cytokines on voriconazole trough concentration in patients with different forms of hematologic disorders. J Clin Pharmacol. Oct 1 2019, 59(10):1340-1350.

9. Xin Zhang, Ming Jin, Yuping Liu, Qimingxing Chen, Luqin Si, Gao Li, Yonghui Zhang, Jiangeng Huang*. Oral bioavailability of kinsenoside in beagle dogs measured by LC-MS/MS: Improvement of ex vivo stability of a lactone-containing compound. Pharmaceutics. Jul 9 2018, 10(3). pii: E87.

10. Li Kang#, Luqin Si#, Jing Rao, Dan Li, Ya Wu, Sanlan Wu, Minghui Wu, Sijie He, Wenwen Zhu, Yang Wu, Jiaqiang Xu, Gao Li, Jiangeng Huang*. Polygoni Multiflori Radix derived anthraquinones alter bile acid disposition in sandwich-cultured rat hepatocytes. Toxicol In Vitro. 2017, 40:313-323. (#Both authors contributed equally)

11. Jiaqiang Xu, Gao Li, Zhuoyi Wang, Luqin Si, Sijie He, Jialing Cai, Jiangeng Huang*, Maureen D. Donovan*. The role of L-type amino acid transporters in the uptake of glyphosate across mammalian epithelial tissues. Chemosphere. 2016, 145:487-494.

学术任职

2024.12--至今 中国药理学会药物代谢专业委员会委员

2024.06--至今 湖北省药理学会药理研究与转化专业委员会常务委员

2022.09--至今 中国药理学会药物代谢专业委员会青年委员会副主任委员

2022.05 国家药品监督管理局CDE《ICH指导原则M12：药物相互作用》专家组成员

2018.06--至今 中国药学会医药生物分析专业委员会委员

2018.04--至今 国家药品监督管理局药物临床试验数据核查专家

2016.01--至今 教育部科技评价与评审专家

2015.05--至今 国家自然科学基金委评审专家

2015.01--至今 教育部学位与研究生教育评估专家

2014.05--至今 《医药导报》编委、常务编委